Aarti Pharmalabs Limited (APL) has transformed from a vendor to a preferred partner. Our two cutting-edge R&D facilities, located in Gujarat's Dombivli and Vapi, consistently strive for:
Route Scouting and Design
New Product Development
Process Optimization and Scale-up
Life Cycle Technology Management Establishing ourselves as a global pharma API and intermediates manufacturer in the pharmaceutical sector is our strategic objective. In the long haul, we want to further embrace open innovation and build a worthwhile, sustainable nutraceutical companies.
We are prepared to seize development possibilities and play a crucial part in establishing our presence in the international pharmaceuticals sector, supported by our knowledge, experience, technical prowess, and resources organisation.
APL has developed expertise in various chemistries and to name a few:
Ammonolysis
Condensation
Chlorination
Denitrochlorination
Diazotization
Ethylation
Halex (Fluorination)
Hydrogenation
Nitration
Sulphonation
Alkylation
Acetylation
Amino Acid Esterification
Aldol Condensation
Asymmetric Hydrogenation
Benzidine Rearrangement
Biocatalysis
Bromination/Sandmeyer
Butyl Lithium Reaction
Balz-Schiemann Reaction
Boron Chemistry
Carboxylation
Cynation
Cyclocondensation
Chichibabin Reaction
Chiral Chemistry (Implementation of enzymatic technology)
Dehydrogenation
Denitrochlorination
Diborane Reduction
Darzens Glycidic Ester Condensation
Darzens Glycidic Ester Condensation
Esterification
Epoxidation
Fluorination: KF, AHF, DHF and Balz Schiemann
Friedel Crafts Reaction
Flow reactor technology at commercial scale
Grignard's Reaction
Hydrogenation/Dehalogenation/Reductive amination
Hetero Diels Alder Reaction
Kolbe Schmitt Reaction
Knoevenagel Reaction
Methoxylation
Meerwein-Ponndorf-Verley Reduction
Michael Addition
Negishi Reaction
Oxidation
Oppenauer Oxidation
Organometallic Coupling
Grignard/Kumada/Suzuki
Phosphorylation
Phosgenation
Ring Alkylation and N-alkylation
Sulfonation
Silylation
Sandmeyer Reaction
Suzuki Coupling
Swern Oxidation
Skraup Reaction
Steroid Chemistry
Triphosgene Reactions
Ullmann Reaction
Vapour phase reaction:
Ammoxidation/Isomerisation
Vilsmeier-Haack Reaction
Wittig Reaction
Willgerodt Reaction
APL has a state-of-the-art analytical laboratory with an experienced and qualified team of scientists engaged in
Typical infrastructure at the Analytical Development laboratory consists of specialised equipment such as HPLC, GC, LCMS, GCMS, Flash-Chromatography, ICP-MS, Particle Size Analyser, NMR and other equipment such as colourimetry, auto-titrator, stability chamber etc.
State of the art synthesis and process development laboratories
With more than 20 PhDs and 80 postgraduate scientists
Reaction workstations are established to conduct various unit reactions
<p>Our labs are equipped with modern experimental set-ups to conduct a range of atmospheric pressure reactions. Fully automated advanced jacketed glass reactor set-ups help in easy control of parameters such as temperature, dosing, pH control dosing while capturing real-time data. We also conduct cryogenic (-80<sup>o</sup>C) and high temperature (>150<sup>o</sup>C) reactions regularly using this cutting-edge set-up.</p>
<p>A dedicated fully automated high-pressure section has been developed with ballast-proof walls. The reactors are remotely controlled by PLC to avoid any exposure to research personnel and meet the best safety standards. Further, software can control gas feeding, temperature control, cooling, liquid feeding, etc., while capturing real-time data. Reactors with various MOCs like SS316, Hastelloy C22, Zirconium, Tantalum, etc. are part of the facility.</p>
<p>Parallel reactors are being used for high throughput screening of reaction parameters and process optimization using statistical design of experiments (DOE) software. Parallel reactors are also used for deviation/What-if studies during process development to optimise development and optimisation time.</p>
<p><strong>React-IR:</strong> Understanding Reaction Kinetics<br /> <strong>FBMR:</strong> Monitor and Control the particle size<br /> <strong>Colorimetric probe: </strong> Understanding heat of the reaction</p>
<p>Jacketed Agitated Nutsche Filter, Centrifuge filter, solvent recovery unit<br /> Additionally, our facility is equipped with an automated distillation apparatus that can achieve separation of compounds with boiling point difference in the range of 1<sup>o</sup>C. This distillation set-up provides flexibility for changing theoretical plates and reflux ratio. The data obtained from the lab helps while scaling up and designing pilot and plant scale distillation set-up. The distillation set-ups are available in different MOCS: Glass, SS316, etc. to ensure different chemistries can be accommodated.</p>
Our waste pre-treatment studies aim to reduce the environmental load at process design stage while targeting various environmentally important parameters such as:
COD
BOD
TSS
pH
TDS
Ammoniacal Nitrogen content
Bromide content
Chloride content
Sulphate content
Metal content
There are essentially four major hazards in chemical processing:
Health and environmental hazards are identified through the in-house SDS generated through GHS compliant software.
The chemical reaction hazards that may be generated during the chemical processing/storage. The three major chemical reaction hazards are:
A dedicated team equipped with advanced laboratory equipment conducts different process safety studies.
We carry out thermal stability tests and other fire and explosion tests especially for powder safety testing. For quick results of powder safety testing, we have also extensive tie ups with third-party service providers. The data from these tests is assessed in-house in our laboratories.
We are also building capabilities and infrastructure for fire and explosion hazards such as
We undertake Hazop studies during the R&D process development to ensure our processes are inherently safe for commercialization
We have developed a Safety Data Sheet (SDS) database of all the GHS compliant products and chemicals being used at APL. This online database is readily accessible to all employees. We also have in-house capabilities to retrieve and generate new MSDS for development products. Being a ‘Responsible Care’ company, such capability of material safety management also helps in establishing product stewardship for existing and new products which helps our employees and customers to take appropriate action and care while handling our chemicals and products.